Jessel, a few questions for you:
What class are you? (nm, duh, just re-read your post, you are a pally)
Do you do a lot of weapon swapping?
Do you do a lot of right-clicking (on armour or weapons)?
Do you prefer to use mouse-clicks or keyboard shortcuts? (ie casting spells, using hotbuttons, targetting groupmates, etc)
Do you like having all your mouse-click stuff gathered in one area or do you let your mouse travel around all over the screen?
Do you want all of your UI windows at the bottom of the screen? the top? down one side? all the way around?
What resolution do you play in?
Could you post a screenshot of your current layout?
(And, I'm moving this to the request forum for you.
)